Chinese Journal of Tissue Engineering Research ›› 2012, Vol. 16 ›› Issue (29): 5350-5354.doi: 10.3969/j.issn. 2095-4344.2012.29. 007

Previous Articles     Next Articles

Platelet-rich fibrin combined with self-setting calcium phosphate cement for repairing jaw defects

Xu Yong-liang1, Wang De-li1, Xu Wen-xiu2   

  1. 1Mudanjiang Medical College, Mudanjiang 157011, Heilongjiang Province, China;
    2Department of Stomatology, Mudanjiang Hongqi Hospital, Mudanjiang 157011, Heilongjiang Province, China
  • Received:2012-03-13 Revised:2012-04-12 Online:2012-07-15 Published:2012-07-15
  • Contact: Wang De-li, Lecturer, Mudanjiang Medical College, Mudanjiang 157011, Heilongjiang Province, China
  • About author:Xu Yong-liang★, Studying for master’s degree, Lecturer, Mudanjiang Medical College, Mudanjiang 157011, Heilongjiang Province, China 89789193@qq.com

PDF

462

Abstract:

BACKGROUND: Choukroun’s platelet-rich fibrin (PRF) and self-setting calcium phosphate cement (CPC) can enhance the repair of bone defects, but either one has its limitation in clinical application. Whether the combination of the two materials can achieve a better effect remains unclear.
OBJECTIVE: To investigate the effect of PRF combined with CPC on jaw defect repair.
METHODS: Totally 40 patients were divided into two groups randomly. The experimental group (n=20) was filled with the combination of PRF and CPC, while the control group (n=20) was filled with CPC only.
RESULTS AND CONCLUSION: In the experimental group, there was a boundary between jaw bone defect area and the surrounding jaw bone tissues, and new bone formed after treatment for 1 month. After 3 months of treatment, the boundaries between bone defect area and the surrounding normal jaw bone tissues were blurred, besides, bone mineral density in bone defect area began to increase and a large number of trabecular bone formed. After 6 months of treatment, the boundaries between the defect area and surrounding normal bone were unclear, and normal bone morphology appeared. In the control group after 6 months of treatment, the boundaries between new bone and the surrounding normal bone were marked, and bone density in the bone cavity of defects area was lower than that in the experimental group at the same period (P < 0.05). These findings suggest that the combination of Choukroun’s PRF and CPC can obviously promote bone growth in patients with jaw defects.

CLC Number: